Then a cloud covered the tent of the congregation, and the glory of the LORD filled the tabernacle.  And Moses was not able to enter into the tent of the congregation, because the cloud abode thereon, and the glory of the LORD filled the tabernacle.  And when the cloud was taken up from over the tabernacle, the children of Israel went onward in all their journeys:  but if the cloud were not taken up, then they journeyed not till the day that it was taken up.  For the cloud of the LORD was upon the tabernacle by day, and fire was on it by night, in the sight of all the house of Israel, throughout all their journeys.
Exodus 40:34-38

After the tabernacle was consecrated for service of the priesthood.  The glory and presence of the LORD filled the tabernacle, and even Moses could not enter.

Now this cloud is a  demonstration of the Holy Spirit’s work in guiding the children of God through the wilderness.  Just as Moses and Israel depended on the LORD’S cloud by day and fire by night; even so the Christian depends on the Holy Spirit for guidance, understanding, wisdom and knowledge.

As Christians, through faith in Jesus Christ, and His finished work on the cross we have received the baptism of the Spirit, so we can be filled with the Spirit, which is walking with God, doing His will.