From previous chapters we see that Isaiah had seen the sin of the people of Israel. It was a time of trial for the nation; the king Uzziah was dead, and he had been a godly leader for the most part.
Because of the death of Uzziah; Isaiah was evidently mourning the death of the king, and he was greatly troubled by the death. It becomes apparent, though, that Isaiah had not seen the Lord of glory. Now things are about to change. Isaiah is about to change. When you see the Lord, exalted, on His throne and that He is holy, holy, holy you too will change for His glory.
When Isaiah saw these angelic beings it seems logical that he fell on his face, and cried these words, “Woe is me! For I am undone; because I am a man of unclean lips, and I dwell in the midst of a people of unclean lips: for mine eyes have seen the King, the LORD of hosts” (6:5). When someone sees Jesus for the first time as the suffering Savior dying on the cross for their sins, their heart cries, ‘Woe is me! I am undone…”. “Undone” simply means sinful, without hope of one’s self. God is holy, holy, holy, and you and I are unholy; yet God seeks to reconcile us to Himself. He could only do this through the death of His righteous, sinless Son.
When you become right with God your desire will be to go for His glory. God asks, “Whom shall I send, and who will go for Us?” Isaiah’s answer was, “Here am I; send me”. that is the answer of a truly grateful heart. That is the answer for the saved, changed, made new heart.
God tells Isaiah, that no one will hear, no one will obey. Isaiah’s answered by asking, “How long do I keep preaching?” God’s answer was, “Until the cities be wasted without inhabitant, and the houses without man, and the land be utterly desolate…” (6:11ff.).
Loving this thrice holy God is a call to faithfulness, not recruiting of numbers. God will give the people. You and I are to keep praying, going, and being faithful.
-Tim A. Blankenship